�Pain Therapeutics, Inc. (NASDAQ: PTIE) and King Pharmaceuticals, Inc. (NYSE: KG) today presented the final data set of a antecedently announced pivotal Phase III study of REMOXY�, an investigational drug to treat chronic pain. The last data confirm REMOXY provides effective day-and-night analgesia inside a patented formulation intentional to dissent common methods of misuse and abuse. The Companies believe this Phase III clinical study is the first to show pain pill efficacy of any twice-daily oxycodone preparation over 12 weeks in a turgid, well-controlled clinical study. REMOXY is currently undergoing a priority review by the U. S. Food and Drug Administration (FDA).
The Companies too presented results of a previously unpublished alcohol interaction study. In this study, human volunteers consumed REMOXY 40 mg with up to eight ounces of 80� proof alcohol to simulate the amount of alcohol consumed in a 'binge drinking' session. Results confirm that REMOXY's conceptualization resists dissolution in alcoholic beverage. REMOXY's lack of a 'dose-dumping' effect is intended to keep the quick, powerful euphoric high that is sought by drug abusers.
These data were presented at the twelfth World Congress of the International Association for the Study of Pain (IASP) in Glasgow, Scotland. IASP is a leading professional forum in the sphere of painfulness, consisting of 6,900 professionals involved in the treatment and research of pain.
"For public wellness reasons, we remain implicated about the abuse of prescription drugs and whatever associated addiction, overdose or deaths," aforesaid Nadav Friedmann, PhD, MD, Chief Operating and Medical Officer at Pain Therapeutics. "Our goals are to encourage physicians to treat legitimate chronic pain and to admonish recreational drug abuse. I believe this updated analysis provides farther evidence of the potential difference for REMOXY to attain these goals."
"The results of these studies further substantiate REMOXY's potential as a utile solution that may offer a new standard in chronic painfulness management," aforementioned Dr. Eric Carter, Chief Science Officer of King. "King is committed to developing unambiguously designed medicines, such as REMOXY, that not only meet the needs of chronic nuisance patients only also assist address the problem of prescription dose abuse and misuse, including use with alcohol, which is presently threatening our communities."
About REMOXY
REMOXY, an investigational drug, is a unique, abuse-resistant, controlled-release oxycodone for moderate-to-severe chronic pain. REMOXY's high viscosity, liquid formulation in a hard gelatin capsule is designed to resist plebeian methods of prescription do drugs misuse and abuse. The New Drug Application (NDA) for REMOXY is presently undergoing a priority limited review by the FDA. The FDA is expected to complete its review of the REMOXY NDA in December 2008. If sanctioned, the Companies believe REMOXY could be the first base oxycodone on the grocery that is designed to reduce the risk of misuse and abuse.
Final Results of the REMOXY Phase III Study
412 patients with osteoarthritis participated in this pivotal study. Final data indicate that the REMOXY study achieved a statistically significant issue in its primary terminus, the reduction in pain in the neck intensity wads over the twelve hebdomad treatment period (p = 0.007), and petty endpoints, including Quality of Analgesia (p = 0.004), Global Assessment (p = 0.007), the pain subscale of the WOMAC Osteoarthritis Index (p=0.023) and the physical component of the SF-12 Health Survey (p=0.003). No drug-related safety issues were renowned in this study. As expected, common opioid-related side-effects were observed in treated patients. A copy of the card presentation is available on Pain Therapeutics' web situation at: hypertext transfer protocol://www.paintrials.com/publications.hTML
About the Alcohol Interaction Study
This was a single-center, randomized, four-way crossover study, designed to pass judgment the effects of fermentation alcohol on the rate and extent of absorption of oxycodone from REMOXY. Thirty-seven human volunteers ingested REMOXY 40mg during each of four treatment sequences that were separated by a 96-hour wash period. Study results confirm that REMOXY maintains its controlled-release mechanism when co-administered with 240mL of 4%, 20% or 40% fermentation alcohol. The co-administration of REMOXY with alcohol did not defeat REMOXY's patented controlled-release mechanism, as evidenced by plasma concentration levels. This lack of 'dose-dumping' is intended to prevent the rapid climb up in oxycodone plasma levels and the resulting euphoric high that is sought by recreational drug abusers. A written matter of the poster intro is useable on Pain Therapeutics' web site at http://www.paintrials.com/publications.html
About Chronic Pain
Approximately 50 million Americans suffer from chronic infliction. Chronic infliction can touch an single throughout his or her life, persistent several weeks, months, or even age at a time. The onset of chronic pain may be nociceptive (caused by ongoing tissue injury), neuropathic (caused by equipment casualty to the brain, spinal cord, or peripheral nerves), or disease specific (such as degenerative joint disease or cancer).
Patients with moderate-to-severe chronic pain a great deal require around-the-clock pain rilievo. However, the under-treatment of pain is a major public health issue complicated by the misuse and abuse of prescription opioids. More than 75 gazillion Americans suffer from pain sensation, which is more than the number of people with diabetes, heart disease and crab combined. While there are a number of prescription pain medications available, the increasing misuse, abuse and diversion of prescription painfulness medications, specially among young people, is having an impact on physicians' ability and/or willingness to treat pain and is clogging patient access to these medicines and appropriate care. Additionally, the increasing misapply, abuse and diversion of opioid pain medications pose a dearly-won and significant public health issue. Pain Therapeutics and King are developing novel drugs to address this problem.
About Oxycodone Abuse
Please visit the U.S. Drug Enforcement Administration's site for more information: click here.
About the Alliance Between Pain Therapeutics, Inc. and King Pharmaceuticals, Inc.
In 2005, King and Pain Therapeutics entered into a strategic alliance to develop and commercialize REMOXY and other abuse-resistant opioid painkillers. Pain Therapeutics is substantially responsible for drug formulation, clinical development and regulatory filings for REMOXY and other abuse-resistant opioid painkillers developed under this alliance. Upon regulatory approval, King will assume sole control and worldwide responsibleness to entirely commercialize REMOXY and other abuse-resistant opioid painkillers. Drug candidates developed under this alliance are unique formulations of the patented Oradur� technology licenced from Durect Corporation.
About Pain Therapeutics, Inc.
Pain Therapeutics is a biopharmaceutical company that develops novel drugs. In addition to REMOXY, the Company has three drug candidates in clinical programs, including PTI-202, Oxytrex� and a novel radio-labeled monoclonal antibody to treat metastatic melanoma. Pain Therapeutics is also working on a new discussion for patients with hemophilia. The FDA has non yet evaluated the merits, safety or efficacy of the Company's drug candidates. For more information, please visit hypertext transfer protocol://www.paintrials.com.
About King Pharmaceuticals, Inc.
King, headquartered in Bristol, Tennessee, is a vertically integrated branded pharmaceutical y. King, an S&P 500 Index company, seeks to capitalise on opportunities in the pharmaceutical diligence through the development, including through in-licensing arrangements and acquisitions, of novel branded prescription pharmaceutical products that complement the Company's focus in specialty-driven markets, peculiarly neuroscience, hospital and sharp care. King strives to be a leader and partner of choice in bringing innovative, clinically-differentiated medicines and technologies to market. http://www.kingpharm.com
Forward-Looking Statements
This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the "Act"). Pain Therapeutics, Inc. and King Pharmaceuticals, Inc. disclaim whatever intent or obligation to update these forward-looking statements, and claim the protection of the Safe Harbor for innovative statements contained in the Act. Examples of such statements include, but ar not limited to, any statements relating to the whether or when the FDA may approve the NDA for REMOXY; the size and scope of the voltage market for REMOXY and the potential benefits of REMOXY or other of the Companies' drug candidates. Such statements are based on management's current expectations, but literal results may differ materially due to various factors. Such statements involve risks and uncertainties, including, merely not limited to, those risks and uncertainties relating to difficulties or delays in exploitation, testing, regulatory approval, production and marketing of the Companies' drug candidates, unexpected delays in the regulative review of the NDA for REMOXY and unexpected adverse side-effects or inadequate therapeutic efficaciousness of the Companies' drug candidates and other factors that could slow or prevent product approval or market toleration (including the risk that current and past results of clinical trials english hawthorn be found to be insufficient for marketing approving). For farther information regarding these and other risks related to the Companies' business, investors should consult the Companies' respective filings with the U.S. Securities and Exchange Commission.
King Pharmaceuticals, Inc.
View drug information on Oxycodone and Aspirin.
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Sunday, 24 August 2008
Thursday, 14 August 2008
Download Ashanti
 Artist: Ashanti: mp3 download Genre(s): R&B: Soul Rap: Hip-Hop Discography:  Can't Stop Year: 2005 Tracks: 11  Concrete Rose Year: 2004 Tracks: 16  Chapter II Year: 2003 Tracks: 20  Ashanti's Christmas Year: 2003 Tracks: 10 With hitmaker Irv Gotti at the helm, Ashanti blamed into the urban music fit in 2002, topping the charts with multiple singles at formerly. She cursorily became a sentiency, gracing the covers of magazines and despotic urban radio receiver. Ashanti built her repute with duets, where she would accompaniment an already popular doorknocker -- Ja Rule ("Always on Time"), Fat Joe ("What's Luv?"), the Notorious B.I.G. ("Unfoolish") -- contrasting the sturdy guy male perspective with her possess. It didn't take the whitney Moore Young Jr. singer long to run into a nominate for herself though: her debut album topped the Billboard album graph scarcely as her debut solo single, "Foolish," was topping the Hot one C graph. Her presence was unavoidable. Ashanti's overnight jump to superstardom followed that of Ja Rule, a similar urban music wizard helmed by Gotti. The New York producer took notice of Ashanti initially because of her beauty, dancing, and playacting. She trained as a dancer at the Bernice Johnson Cultural Arts Center, learning a number of dance styles. She danced most notably in Disney's Polly, which asterisked Phylicia Rashad, and as well appeared in a number of big-name music videos, in addition to other dance work. As an actress, she made a mention for herself with roles in Spike Lee's Malcolm X and Who's da Man earlier that. The multi-talented vocalizer was causing quite a stir, and Gotti did what he could to bring her into his Murder Inc. fold. After showcasing her lightheaded voice on Big Pun's "How We Roll" and the Truehearted and Furious soundtrack -- both in 2001 -- Gotti set Ashanti to work out on her debut album, which he produced. Success came promptly. A duo with Ja Rule, "Always on Time," hit number one on Billboard's Hot one C graph in early 2002 exactly as a duet with Fat Joe, "What's Luv?," was creep toward the same number one position. These iI airplay-heavy singles fix the stage perfectly for Ashanti's self-titled debut exit. The album's lead single, "Goosey," raced up the Hot one C graph, incoming the Top Ten in March aboard "Always on Time" and "What's Luv?," giving her trey Top Ten songs in the like week, including the number one and two positions -- a quite dramatic exploit. And then Ashanti's album debuted at number one on the album chart, selling an astounding D,000-plus copies in its first week. With all this chart-topping, Ashanti congeal some gross sales records and her success continued. Gotti readied a remix of "Foolish," titled "Unfoolish," that featured the Notorious B.I.G. and once more overtook urban radio, where no artist was more ubiquitous throughout 2002 than Ashanti. She returned the following year with Chapter II, which alike topped the Billboard album graph on the heels of its hot wind single, "Rock and roll Wit U (Awww Baby)." The album's success was jolly eclipsed, however, by all the negative drama circumferent the Murder Inc. camp at the time (i.e., the FBI investigating and the G-Unit feuding). A Christmas album followed former that class, and Concrete Rose appeared in December 2004. Though she remained with The Inc. for 2007's The Declaration, she sought-after out a number of producers (including Robin Thicke, Pharrell Williams, and Dr. Dre) outside the label's in-house team. |
Temper D and K Fire
Friday, 27 June 2008
Danny Byrd
Artist: Danny Byrd
Genre(s):
Drum & Bass
Discography:
Soul Function / Junction 18
Year: 2005
Tracks: 2
NHS97 DD
Year: 2005
Tracks: 2
NHS42
Year: 2002
Tracks: 1
Thursday, 19 June 2008
Robbie Williams With Pet Shop Boys
Artist: Robbie Williams With Pet Shop Boys
Genre(s):
Pop
Discography:
Shes Madonna
Year: 2007
Tracks: 2
Wednesday, 11 June 2008
Boy George Answers Prayers of NYC’s Sanitation Workers
Photo: Getty Images
Wonderful news! Boy George has just announced plans to play a free concert at New York City's Department of Sanitation Family Day on August 17! According to a press release, George will perform "all his Culture Club hits" as his way to say thanks to those who made his recent court-mandated community service such an enjoyable experience. Says overjoyed DSNY First Deputy Commissioner Michael Bimonte:
"New York's Strongest are delighted that Boy George will join us at our Family Day outing in August and perform some of his fabulous hits for our hard-working men and women and their families. Keeping New York City safe and clean is a daunting challenge — as Boy George well knows — and we welcome his generous offer to entertain those who have made our City the cleanest it has been in more than 30 years."
Update: Terrible news! In response to our query about where we might purchase tickets, Boy George's publicist says, "It's only for the Sanitation Department workers unfortunately."
Wonderful news! Boy George has just announced plans to play a free concert at New York City's Department of Sanitation Family Day on August 17! According to a press release, George will perform "all his Culture Club hits" as his way to say thanks to those who made his recent court-mandated community service such an enjoyable experience. Says overjoyed DSNY First Deputy Commissioner Michael Bimonte:
"New York's Strongest are delighted that Boy George will join us at our Family Day outing in August and perform some of his fabulous hits for our hard-working men and women and their families. Keeping New York City safe and clean is a daunting challenge — as Boy George well knows — and we welcome his generous offer to entertain those who have made our City the cleanest it has been in more than 30 years."
Update: Terrible news! In response to our query about where we might purchase tickets, Boy George's publicist says, "It's only for the Sanitation Department workers unfortunately."
Thursday, 5 June 2008
Sabrina star Melissa Joan Hart gives birth
Melissa Joan Hart and her husband Mark Wilkerson have welcomed their second child, a baby boy.
According to People magazine, the 31-year-old actress, best known for role in 'Sabrina the Teenage Witch', gave birth to a 7lbs 3oz baby yesterday afternoon.
The couple, who married in 2003, already have a two-year-old son called Mason.
Hart previously said: "This has been a long but exciting pregnancy, and we along with Mason are excited to add to the Wilkerson clan."
According to People magazine, the 31-year-old actress, best known for role in 'Sabrina the Teenage Witch', gave birth to a 7lbs 3oz baby yesterday afternoon.
The couple, who married in 2003, already have a two-year-old son called Mason.
Hart previously said: "This has been a long but exciting pregnancy, and we along with Mason are excited to add to the Wilkerson clan."
Tuesday, 27 May 2008
Martin Sheen Honoured For Humanitarian Effort
Activist-actor Martin Sheen will be honoured by the University of Notre Dame for his humanitarian work, the college announced yesterday.
The NUI Galway graduate starred in 'The West Wing' playing a U.S. president who was a Notre Dame graduate and he is set to receive the 'Laetare Medal' at a ceremony in the college on 18 May. President John F. Kennedy is amongst previous recipients of the award.
Talking about the famous actor, the university's president, the Rev. John I. Jenkins Sheen said: "He has used that celebrity to draw the attention of his fellow citizens to issues that cry out for redress, such as the plight of immigrant workers and homeless people, the waging of unjust war, the killing of the unborn and capital punishment".
The 67-year-old has described himself as a Catholic peace activist. He has been arrested for taking part in non-violent demonstrations against various U.S. military policies.
He has donated money and time to such causes as the alleviation of poverty and homelessness, human rights for migrant workers and environmental protection.
The NUI Galway graduate starred in 'The West Wing' playing a U.S. president who was a Notre Dame graduate and he is set to receive the 'Laetare Medal' at a ceremony in the college on 18 May. President John F. Kennedy is amongst previous recipients of the award.
Talking about the famous actor, the university's president, the Rev. John I. Jenkins Sheen said: "He has used that celebrity to draw the attention of his fellow citizens to issues that cry out for redress, such as the plight of immigrant workers and homeless people, the waging of unjust war, the killing of the unborn and capital punishment".
The 67-year-old has described himself as a Catholic peace activist. He has been arrested for taking part in non-violent demonstrations against various U.S. military policies.
He has donated money and time to such causes as the alleviation of poverty and homelessness, human rights for migrant workers and environmental protection.
Tuesday, 20 May 2008
Carey sets date for her new album
Carey sets date for her new album
Mariah Carey has announced full inside information of her new album, 'That Chick'.
Billboard reports that the album will be released on 1 April and showcases Carey's talents as a down, ballad and R&B vocalist.
Among those wHO feature worked with Carey on the album ar producers will.i.am, Jermaine Dupri and Rodney Jerkins and reggae star Damian Marley.
The full tracklisting for the album is:'Lovin' You Long Time''Touch My Body''That Chick''Thanx for Nothin'''For the Record''Migrate''Cruise Control''Love Story''OOC''Bye
Sunday, 18 May 2008
Emmerdale star tells of real-life abuse
Emmerdale star tells of real-life abuse
'Emmerdale' actress Roxanne Pallett has spoken about how her stream domestic blackguard storyline has brought plump for memories of a real life abusive relationship.
In 'Emmerdale' Pallett's type Jo Sugden is the victim of psychological and house servant fury at the hands of her married man Andy (Kelvin John Fletcher), world Health Organization has latterly been released from pokey.
The 25-year-old actress told 'This Morning' that the plot line was difficult to film because she once establish herself in a similar situation in real life.
Pallett said: "K and I own been animation this storyline since Noel and you're researching it and it brings it entirely back to you and it's devastating."
"I can't still watch these scenes back without it choking me up. I watched it with my mum and we just saturday and she held my hand through it altogether because it's devastating."
The actress also said: "And what you're beholding is just now a fraction of what people ar still going away through."
When asked if her mother knew that she was in an abusive relationship, Pallett said: "She got me come out of the closet of it."
"A booster plant out and she was my john Rock. And then my mammy found out and it was merely then that I thought process, 'This is it now, I'm at a crossroads in my lifespan where I tin either retain in this spiral or I toilet take out'.
"It just takes one individual and you receive to just severalise ace person and confide in one person. Citizenry turn a blind eye, citizenry don't need to know other people's problems."
Speaking close to her plot line, she said: "We penury to bestow this field of study to the forefront where women are watching it."
"Not just now women, I'm sure there are spate of manpower in that state of affairs where women ar controlling work force... Only there's people entirely over the land that I'm certainly tonight testament be sitting thither and they'll see Andy and Jo at home and they'll be observation it. Behind closed doors they're agony from that."
Nine films on Foreign Oscar longlist
Zero Hour
Artist: Zero Hour
Genre(s):
Rock
Metal: Progressive
Discography:
Fragile Mind
Year: 2005
Tracks: 9
Metamorphosis
Year: 2003
Tracks: 12
Liberalist metallic element getup Nothing Hour was formed in the San Francisco Embayment surface area in 1993 by brothers Ilium (fresh water freshwater bass) and Jasun Tipton (guitar), along with longtime supporter Mike Hombre (drums). The hunt for a vocaliser seemed to be over when Wienerwurst Mendez (at one prison term of Rogue's Heading) joined in 1995, along with keyboardist Mike Conner (ex-Prodigy -- non the electronica mathematical group or the hip-hop creative person). Nonetheless, Mendez was gone onward year's end, and Conner helped enter his early on bandmate Erik Rosvold to dramatize Mendez's lieu. Unluckily, Conner developed wrist bone bone burrow syndrome as the chemical substance group was preparing to rail disc its debut album in 1997, and was forced to leave. His position was taken on record script by the tag team of Matt Guillory and Phil Floyd Bennett, both veterans of many a prog seance. The ring self-released its self-produced, self-titled mini-album in 1998, and it at last landed Zero point Hour a deal with the neo-prog tag Laser's Edge/Sensory. Their major tag debut, The Towers of Avariciousness, was issued in ahead of time 2001.
Winehouse helps Ronson through break-up
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